New study links strains of gut microbiota to m

(May 4, 2022, Lyon, France) A new study has identified strains of gut microbiota associated with more severe strokes and poorer post-stroke recovery, revealing that the gut microbiome may be an important factor in risk of stroke and its results1.

The study, presented today at the European Stroke Organization Conference (ESOC 2022), identified specific groups of bacteria associated with poorer neurological recovery after ischemic stroke, both in the acute phase (24 hours) and after three months.

Research has identified several types of bacteria associated with ischemic stroke risk, including Fusobacterium and Lactobacillus. Negativibacillus and Lentisphaeria were associated with more severe stroke in the acute phase (at 6 and 24 hours respectively) and Acidaminococcus linked to poor functional outcome at three months.

Dr Miquel Lledós, lead author from the Pharmacogenomics and Stroke Genetics Laboratory at the Sant Pau Research Institute, Barcelona, ​​Spain, said: “The influence of the gut microbiome – the trillions of bacteria and other microorganisms that live in the gut – is a modifiable risk factor associated with stroke risk and with post-stroke neurological outcomes. However, most research has already been done in animal models.

“In this study, we collected fecal samples – the first samples taken after the event – ​​from 89 humans who had suffered an ischemic stroke. By comparing with a control group, we were able to identify several groups of bacteria associated with a higher risk of ischemic stroke.

An ischemic stroke occurs when a clot or other blockage blocks the blood supply to the brain and is the most common type of stroke. In Europe, 1.3 million people suffer a stroke each year and it is the second most common cause of death.2.

“This discovery opens up the exciting prospect that in the future, we may be able to prevent strokes or improve neurological recovery by examining the gut microbiota. In other pathologies, clinical trials are underway where researchers replace gut flora with dietary changes or fecal transplantation from healthy individuals and this should be further investigated in the area of ​​stroke.

The association between certain strains of gut bacteria and the risk of ischemic stroke has been strengthened in another study presented at ESOC this week by a team from Yale University, Connecticut, USA3.

The researchers analyzed statistics from the Flemish Gut Flora project and the MEGASTROKE consortium, using a technique called Mendelian randomization (MR) which measures gene variation to examine the causal effect of an outcome or exposure. The study identified 20 microbial traits significantly associated with the risk of developing at least one ischemic stroke subtype.

ENDS

Notes to editors:

A reference to the European Stroke Organization (ESO) conference should be included in any coverage or article associated with this study and research.

For more information or to arrange an interview with an expert, please contact Luke Paskins or Sean Deans at [email protected], [email protected] or [email protected], or call + 44 (0) 208 154 6396.

About the author of the study:

Dr. Miquel Lledós is from the Pharmacogenomics and Stroke Genetics Laboratory at the Sant Pau Research Institute, Barcelona, ​​Spain.

About ESO:

The European Stroke Organization (ESO) is a pan-European society of stroke researchers and doctors, national and regional stroke societies and non-professional organisations, founded in December 2007. ESO is an NGO made up of individual and organizational members. The goal of ESO is to reduce the burden of stroke by changing the way stroke is viewed and treated. This can only be achieved through professional and public education and by making institutional changes. ESO is the voice of stroke in Europe, harmonizing stroke management across Europe and taking action to reduce the burden.

Four facts about stroke:

  1. In 2017, there were 1.12 million first strokes in the EU, 9.53 prevalent stroke cases and 460,000 stroke-related deaths4
  2. In 2017, 7.06 million disability-adjusted years were lost due to stroke in the EU4
  3. By 2047, it is estimated that there will be 40,000 additional strokes per year in the EU (a 3% increase).4
  4. 80% of premature heart disease and stroke are preventable5

References:

  1. Influence of the Gut Microbiome on Ischemic Stroke Risk and Ischemic Stroke Outcome, presented at the European Stroke Organization Conference, May 4, 2022.
  2. status and prospects of acute stroke care in Europe | Stroke (ahajournals.org)
  3. The gut microbiome influences the risk of acute ischemic stroke: a Mendelian randomization study, presented at the European Stroke Organization Conference, May 5, 2022.
  4. https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.029606
  5. https://www.euro.who.int/en/health-topics/noncommunicable-diseases/cardiovascular-diseases/data-and-statistics

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